GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4812048 | 1 | rs55905547 | chr20:57589995 | TH1L | chr20:57556311-57570186:+ | -0.17 | -3.84 | 0.000139 | Mean platelet volume |
| THCA | cis | rs867186 | 1 | rs55909363 | chr20:33549407 | PROCR | chr20:33758727-33765164:+ | -0.36 | -5.62 | 3.24E-8 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs867186 | 1 | rs55909363 | chr20:33549407 | TRPC4AP | chr20:33590215-33680618:- | 0.32 | 3.82 | 0.00015 | Anticoagulant levels;D-dimer levels;Protein C levels;Factor VII levels;Hemostatic factors and hematological phenotypes |
| THCA | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 12.9 | 7.22E-33 | Height |
| THCA | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | CEP63 | chr3:134204575-134293852:+ | 0.3 | 6.55 | 1.51E-10 | Height |
| THCA | cis | rs80285556 | 1 | rs55914901 | chr19:50528346 | SIGLEC16 | chr19:50472912-50479075:+ | 0.55 | 5.36 | 1.31E-7 | antipsychotic drug dosage in schizophrenia or schizoaffective disorder |
| THCA | cis | rs1027730 | 1 | rs55918136 | chr8:94081231 | C8orf83 | chr8:93895865-94029901:- | 0.27 | 4.33 | 1.78E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2084898 | 1 | rs55920307 | chr11:120042846 | TRIM29 | chr11:119981995-120008863:- | 0.42 | 6.97 | 1.03E-11 | Stroke (pediatric) |
| THCA | cis | rs6978712 | 1 | rs55921267 | chr7:127148361 | GRM8 | chr7:126078652-126893147:- | -0.35 | -3.57 | 0.000398 | Medication adherence in chronic diseases |
| THCA | cis | rs73201462 | 1 | rs55925538 | chr3:128042877 | EEFSEC | chr3:127872313-128127488:+ | -0.21 | -3.7 | 0.000237 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs12618769 | 1 | rs55934348 | chr2:99246885 | UNC50 | chr2:99225042-99234975:+ | -0.23 | -4.53 | 7.44E-6 | Bipolar disorder |
| THCA | cis | rs60843830 | 1 | rs55936726 | chr2:258210 | SH3YL1 | chr2:218138-264810:- | -0.95 | -26.61 | 2.24E-96 | Spherical equivalent (joint main effects and education interaction) |
| THCA | cis | rs7216064 | 1 | rs55939964 | chr17:65869297 | C17orf58 | chr17:65987218-65989765:- | 0.2 | 3.97 | 8.17E-5 | Lung adenocarcinoma;Lung cancer;EGFR mutation-positive lung adenocarcinoma |
| THCA | cis | rs2278170 | 1 | rs55940502 | chr11:4484737 | TRIM68 | chr11:4619902-4629437:- | 0.16 | 3.69 | 0.000253 | Amyotrophic lateral sclerosis |
| THCA | cis | rs8030605 | 1 | rs55942364 | chr15:56512961 | MNS1 | chr15:56720929-56757335:- | -0.23 | -3.41 | 0.000699 | Waist-to-hip ratio adjusted for body mass index |